Meropenem

Restricted
C. diff Risk

Medium

Oral Bioavailability

NA

Dosing

eGFR 0 - 10 eGFR 10 - 25 eGFR 25 - 50 eGFR > 50 500mg IV q24h500mg - 1g IV q12h500mg -1g IV q12h500 mg IV q6h OR 1g IV q8h

eGFR 0 - 10 eGFR 10 - 25 eGFR 25 - 50 eGFR > 501g IV 24h2g IV q12h2g IV q12h2g IV q8h

500mg IV q24h

Dose after HD on dialysis days

1g IV q8h

Depends on flow rate

Standard Dose
500mg IV q6h or 1g IV q8h

Meningitis
2g IV q8h

Must be approved by Infectious Diseases or Critical Care

This antimicrobial is restricted to Infectious Diseases and Adult Critical Care

General Information

  •  Immediate and delayed-type allergy

  •  GI disturbance

  •  Cytopenias, positive Coombs

  •  Liver enzyme abnormalities

Therapy of serious, often nosocomial infections involving resistant Gram negative organisms

Valproic acid - Carbapenems decrease valproate levels and may decrease seizure threshold

Antimicrobial class: Carbapenem

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Moderate

Biliary penetration: Therapeutic