Meropenem - Renal Dosing

In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.

If worsening renal function, actual GFR is likely lower than calculated.

If improving renal function, actual GFR is likely higher than calculated eGFR.

eGFR 0 - 10

500mg IV q24h

eGFR 10 - 25

500mg - 1g IV q12h

eGFR 25 - 50

500mg -1g IV q12h

eGFR > 50

500 mg IV q6h OR 1g IV q8h

eGFR 0 - 10

1g IV 24h

eGFR 10 - 25

2g IV q12h

eGFR 25 - 50

2g IV q12h

eGFR > 50

2g IV q8h

500mg IV q24h

Dose after HD on dialysis days

1g IV q8h

Depends on flow rate