C. diff Risk


Oral Bioavailability


Approximate Cost


100mg IV load on day 1 then 50mg IV q12h

Severe Impairment - Child Pugh C
100mg load on day 1 then 25mg IV daily

No dosage adjustment required

This antimicrobial is restricted to Infectious Diseases

General Information

Common Usage

Reserved for highly resistant infections or when significant allergies restrict other options and when there is documented susceptibility.

Associated with more treatment failures than alternatives and excess mortality - Black Box Warning.

Adverse Effects

Avoid or use with caution in patients with tetracycline reactions.

GI side effects very prominent with significant nausea and vomiting.

Tetracycline related adverse events: photosensitivity, acute pancreatitis.

Rash, abnormal liver enzymes.

Major Interactions

Oral contraceptives less effective.

Additional Information

Requires Infectious Disease consultation.

Documented safety concerns in bacteremia especially.


Antimicrobial class: Tetracycline derivative

Pregnancy category: D

Average serum half life: 42 hours

Biliary penetration: Therapeutic

Lung penetration: Therapeutic