100mg IV load on day 1 then 50mg IV q12h
Severe Impairment - Child Pugh C
100mg load on day 1 then 25mg IV daily
No dosage adjustment required
This antimicrobial is restricted to Infectious Diseases
Reserved for highly resistant infections or when significant allergies restrict other options and when there is documented susceptibility.
Associated with more treatment failures than alternatives and excess mortality - Black Box Warning.
Avoid or use with caution in patients with tetracycline reactions.
GI side effects very prominent with significant nausea and vomiting.
Tetracycline related adverse events: photosensitivity, acute pancreatitis.
Rash, abnormal liver enzymes.
Oral contraceptives less effective.
Requires Infectious Disease consultation.
Documented safety concerns in bacteremia especially.
Antimicrobial class: Tetracycline derivative
Pregnancy category: D
Average serum half life: 42 hours
Biliary penetration: Therapeutic
Lung penetration: Therapeutic