Amoxicillin-clavulanate

C difficile risk
Medium
Oral Bioavailability
Excellent

Dosing

eGFR 0 - 10eGFR 10 - 50eGFR > 50250-500mg PO q24h of amoxicillin component 250-500mg PO q12h of amoxicillin component 500mg PO q8h of amoxicillin component

250-500mg PO q24h of amoxicillin component

875mg PO BID or 500mg PO TID of the amoxicillin component

General Information

Prophylaxis and treatment of human and animal bite wounds.

Polymicrobial infections involving the respiratory tract or abdomen.

Skin and soft tissue infections.

For prolonged therapy, monitor renal and hepatic function.

  • Allergy/rash

  • Cytopenias

  • Gastrointestinal intolerance

  • Clostridium difficile associated diarrhea

Allopurinol - increased risk of rash

Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic