Serious HSV/VZV Infections (e.g. CNS Infections and Disseminated Herpes Zoster)
10mg/kg IV q8h
800mg PO five times per day
Prophylaxis dosing varies by indication
Acyclovir is used to treat herpes virus infections (e.g. HSV and VZV) but not CMV infections.
Acyclovir is also used for prophylaxis in transplantation protocols for patients who are immunocompromised.
Monitor serum creatinine and monitor for neurotoxicity.
Phlebitis with IV formulation
Increased serum creatinine and hematuria secondary to crystal nephropathy
Mycophenolate can increase serum concentrations of acyclovir.
For indications when oral acyclovir can be used, valacyclovir is the pro-drug, which is more bioavailable with more convenient dosing.
Antimicrobial class: Antiviral. Nucleoside analogue.
Pregnancy category: B
Average serum half life: 3 hours
CSF penetration: Therapeutic
Urine penetration: Therapeutic