Penicillin VK

C. diff Risk


Oral Bioavailability


Approximate Cost


250-500mg PO q6-8h

General Information

Common Usage

Streptococcal infections and therapy of documented susceptible infection not requiring parenteral therapy (i.e. upper respiratory tract).

Prophylaxis after rheumatic fever.

Drug Monitoring

  • ┬áMonitor for allergy.

  • ┬áPeriodic CBC, SCr

Adverse Effects

  • Allergy (anaphylaxis) and other rash

  • Cytopenias, Positive Coombs, Eosinophilia

  • Serum sickness

  • AIN

Major Interactions

No significant interactions


Antimicrobial class: Penicillin

Pregnancy category: B

Average serum half life: 1 hour

Lung penetration: Therapeutic

Urine penetration: Therapeutic