1-2g IV q8h (max 6 g/day)
Skin and Soft Tissue Infections
1g IV q8h
MSSA Bacteremia OR Infective Endocarditis OR Osteomyelitis
2g IV q8h
Cefazolin is often used in treatment for skin and soft tissue infections, providing coverage for MSSA and beta-hemolytic Streptococcus spp.
Cefazolin is also used in treatment of deep space, invasive infections such as osteomyelitis and infective endocarditis, secondary to MSSA.
Cefazolin can be associated with a positive Coombs test, cytopenias, as well as hepatic and renal laboratory abnormalities.
Clostridium difficile associated diarrhea
Antimicrobial class: 1st Generation Cephalosporin
Pregnancy category: B
Average serum half life: 2 hours
Biliary penetration: Therapeutic
CSF penetration: Poor
Lung penetration: Therapeutic
Urine penetration: Therapeutic