Usual dosing 2g IV q4-12h Intra-abdominal Infections 1-2g IV q6-8h Spontaneous Bacterial Peritonitis 2g IV q8h Bacterial Meningitis 2g IV q4h
Cefotaxime is commonly used in the treatment of bacterial meningitis, community-acquired pneumonia and intra-abdominal infections.
The spectrum of activity of cefotaxime is similar to that of ceftriaxone but requires multiple daily dosing and renal adjustment. Consider using ceftriaxone as an alternative.
Positive Coombs test
Elevated liver enzymes
Clostridium difficile associated diarrhea
Antimicrobial class: 3rd Generation Cephalosporin
Pregnancy category: B
Average serum half life: 1.5 hours
Biliary penetration: Moderate
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Therapeutic