Cefotaxime - Renal Dosing

In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.

If worsening renal function, actual GFR is likely lower than calculated.

If improving renal function, actual GFR is likely higher than calculated eGFR.

eGFR 0 - 10

2g IV q24h

eGFR 10 - 50

2g IV q12h-24h

eGFR > 50

2g IV q8-12h

1-2g IV q24h

Dosed after HD on dialysis days

1-2g IV q8-12h