Cefuroxime

C. diff Risk

Medium

Oral Bioavailability

Moderate

Dosing

eGFR 0 - 10eGFR > 10250mg PO q24h500mg PO BID

eGFR 0 - 10eGFR 10 - 20eGFR > 200.75-1.5g IV q24h0.75-1.5g IV q12h0.75-1.5g IV q8h

750-1500mg IV q24h

750mg PO

Give dose after HD on dialysis days.

750-1500mg IV q8h

Usual dose
750-1500mg IV q8h

500mg PO BID

General Information

Adverse Effects

  •  Allergy/rash

  •  Positive Coombs test

  •  Cytopenias

  •  Gastrointestinal intolerance

  • Clostridium difficile associated diarrhea

  •  Abnormal liver enzymes

Common Usage

Cefuroxime is commonly used for community-acquired pneumonia

Major Interactions

No significant interactions.

Pharmacology

Antimicrobial class: 2nd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic