Cefuroxime - Renal Dosing

In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.

If worsening renal function, actual GFR is likely lower than calculated.

If improving renal function, actual GFR is likely higher than calculated eGFR.

eGFR 0 - 10

250mg PO q24h

eGFR > 10

500mg PO BID

eGFR 0 - 10

0.75-1.5g IV q24h

eGFR 10 - 20

0.75-1.5g IV q12h

eGFR > 20

0.75-1.5g IV q8h

750-1500mg IV q24h

750mg PO

Give dose after HD on dialysis days.

750-1500mg IV q8h