Caspofungin

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Restricted

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

Dosing

Adult

70 mg IV x 1 dose, then 50 mg IV daily

Use must be approved by Infectious Diseases.

Hepatic

Adult, moderate (Child-Pugh score B-C)
70 mg IV x 1, then 35 mg IV daily

Use must be approved by Infectious Diseases.

Renal

No adjustment necessary

General Information

Common Usage

Caspofungin is often used in management of suspected and confirmed invasive fungal infections, particularly Candidiasis and Aspergillosis

Drug Monitoring

  • Liver enzymes at baseline and every 1-2 weeks

Adverse Effects

  • Infusion-related reactions (rash, pruritis)

  • Phlebitis

  • Headache

  • Nausea and vomiting

  • Elevations in hepatic enzymes

Additional Information

Caspofungin has poor vitreous, CNS and urinary penetration. It should not be used for treatment of Candida urinary tract infections.

Use must be approved by Infectious Diseases.

Pharmacology

Antimicrobial class: Echinocandin

Urine penetration: Poor

Lung penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic