70 mg IV x 1 dose, then 50 mg IV daily
Use must be approved by Infectious Diseases.
Adult, moderate (Child-Pugh score B-C)
70 mg IV x 1, then 35 mg IV daily
No adjustment necessary
Caspofungin is often used in management of suspected and confirmed invasive fungal infections, particularly Candidiasis and Aspergillosis
Infusion-related reactions (rash, pruritis)
Nausea and vomiting
Elevations in hepatic enzymes
Caspofungin has poor vitreous, CNS and urinary penetration. It should not be used for treatment of Candida urinary tract infections.
Antimicrobial class: Echinocandin
Urine penetration: Poor
Lung penetration: Therapeutic
CSF penetration: Poor
Biliary penetration: Therapeutic