Clostridium perfringens


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General Information

Anaerobic spore forming gram positive bacilli, box-car shaped.

Environmental (soil, water) organism as well as human/animal digestive tract.

Associated with penetrating wounds with environmental exposure.

  • ¬†Gas gangrene

  • Clostridial myonecrosis

  • ¬†Necrotizing fasciitis

  • Intra-abdominal abscess

  • Empyema

  • Fatal bacteremia with massive exotoxin-mediated hemolysis

  • Foodborne self-limited gastrointestinal illness

In cases of gas gangrene or necrotizing fasciitis, prompt surgical debridement is critical. Strongly consider consultation with Surgery and Infectious Diseases. Combination of penicillin and clindamycin should be considered in patients with necrotizing fasciitis or clostridial myonecrosis.