Hemodynamically unstable or severe infection
Initial Empiric Treatment
Subsequent dosing frequency depends on renal function. Continue vancomycin until susceptibility are available.
Duration of Therapy
Treat for a minimum of 2 weeks after first negative blood culture if patient has no complicating factors:
Infective endocarditis has been excluded
No implanted prostheses are present
Follow up blood cultures drawn 2-4 days after the initial set are sterile
The patient defervesces within 72 hours of initiation of effective antibiotic therapy
No evidence of metastatic infection is present on examination
Longer treatment duration is needed for patients who have complicated Staphylococcus aureus bacteremia. Strongly consider consultation with Infectious Diseases.