500 mg IV q6h
0 - 30 eGFR31 - 5050+500 mg IV q12h500 mg IV q8h500 mg IV q6h
250-500 mg IV q12h (after dialysis on dialysis days)
500 mg IV q6-8h
Immediate and delayed-type allergy
Cytopenias, positive Coombs
Liver enzyme (increased AST/ALT)
CNS effects including confusion, seizures
C difficile colitis
May decrease serum concentrations of valproic acid.
May increase risk of seizures with ganciclovir, valganciclovir.
Cyclosporine may increase risk of seizures with imipenem.
Antimicrobial class: Carbapenem
Average serum half life: 1 hour
CSF penetration: yes, but meropenem preferred for CNS infections due to seizure risk with imipenem-cilastatin