Antimicrobials

Imipenem-Cilastatin

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

$28/day

Dosing

500 mg IV q6h

General information

  •  Immediate and delayed-type allergy

  •  GI upset

  •  Cytopenias, positive Coombs

  •  Liver enzyme (increased AST/ALT)

  •  CNS effects including confusion, seizures

  •  C difficile colitis

May decrease serum concentrations of valproic acid.

May increase risk of seizures with ganciclovir, valganciclovir.

Cyclosporine may increase risk of seizures with imipenem.

Antimicrobial class: Carbapenem

Average serum half life: 1 hour

CSF penetration: yes, but meropenem preferred for CNS infections due to seizure risk with imipenem-cilastatin