C. diff Risk


Oral Bioavailability


Approximate Cost


Spectrum Of Activity


500 mg IV q6h

0 - 30 eGFR31 - 5050+500 mg IV q12h500 mg IV q8h500 mg IV q6h

250-500 mg IV q12h (after dialysis on dialysis days)

500 mg IV q6-8h

General Information

Adverse Effects

  •  Immediate and delayed-type allergy

  •  GI upset

  •  Cytopenias, positive Coombs

  •  Liver enzyme (increased AST/ALT)

  •  CNS effects including confusion, seizures

  •  C difficile colitis

Major Interactions

May decrease serum concentrations of valproic acid.

May increase risk of seizures with ganciclovir, valganciclovir.

Cyclosporine may increase risk of seizures with imipenem.


Antimicrobial class: Carbapenem

Average serum half life: 1 hour

CSF penetration: yes, but meropenem preferred for CNS infections due to seizure risk with imipenem-cilastatin