Penicillin VK

C. diff Risk

Low

Oral Bioavailability

Moderate

Approximate Cost

$0.50/day

Dosing

Adult

250-500mg PO q6-8h

General Information

Common Usage

Streptococcal infections and therapy of documented susceptible infection not requiring parenteral therapy (i.e. upper respiratory tract).

Prophylaxis after rheumatic fever.

Drug Monitoring

  • ┬áMonitor for allergy

  • ┬áPeriodic CBC, SCr

Adverse Effects

  • Allergy (anaphylaxis) and other rash

  • Cytopenias, Positive Coombs, Eosinophilia

  • Serum sickness

  • AIN

Major Interactions

No significant

Pharmacology

Antimicrobial class: Penicillin

Pregnancy category: B

Average serum half life: 1.0

Lung penetration: Therapeutic

Urine penetration: Therapeutic