Restricted
Hospital Formulary Status Yes (parenteral inj)
In-Hospital Cost will be updated
PharmaCare Formulary Status No
Special Authority None
PharmaCare Coverage None
Outpatient Cost 1g powder for soln/inj - $53.50-68.03/vial
Targeted therapy of ESBL infections and other resistant gram negative infections.
Empiric therapy when broad spectrum of carbapenems is desired without the need for anti-pseudomonal activity.
Restrictions Status: Yes (inj)
Restricted to outpatient use only:
1) Empiric therapy: Severe Gram-negative or polymicrobial infections with risk factors for resistance, or when other antibiotics are contraindicated due to allergy or intolerance
OR
2) Directed therapy: Gram-negative or polymicrobial infection resistant to other antibiotics (e.g. ceftriaxone, fluoroquinolones, cotrimoxazole), or when other antibiotics are contraindicated due to allergy, intolerance or unavoidable logistical circumstances
Note: Pharmacists are NOT required to enforce compliance with new provincial ‘indication based’ restrictions at the time of order verification.
For additional assistance in optimizing this order, contact an Antimicrobial Stewardship pharmacist, medical microbiologist on call or an ID physician.
Acute liver injury (mainly with IV)
Neutropenia (mainly with IV)
Thrombocytopenia (mainly with IV)
Allergic interstitial nephritis (mainly with IV)
Pulmonary infiltrate with eosinophilia (PIE) syndrome (mainly with IV)
CNS toxicity (mainly with IV)
Allergic reaction (PO and IV)
Serum sickness (PO and IV)
Rash (PO and IV)
Note: EBV-related rash - not an allergy
Antimicrobial class: Carbapenem
Pregnancy category: B
Average serum half life: 4.0 hr
Urine penetration: Therapeutic
Lung penetration: Therapeutic
Biliary penetration: Moderate