Tigecycline

Restricted
Restricted

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

$$$$

Dosing

Adult

100mg IV load on day 1 then 50mg IV q12h

Hepatic

Severe Impairment - Child Pugh C
100mg load on day 1 then 25mg IV daily

General Information

Common Usage

Reserved for highly resistant infections or when significant allergies restrict other options and when there is documented susceptibility.

Associated with more treatment failures than alternatives and excess mortality - Black Box Warning.

Adverse Effects

Avoid or use with caution in patients with tetracycline reactions.

GI side effects very prominent with significant nausea and vomiting.

Tetracycline related adverse events: photosensitivity, acute pancreatitis.

Rash, abnormal liver enzymes.

Major Interactions

Oral contraceptives less effective.

Additional Information

Requires Infectious Disease consultation.

Documented safety concerns in bacteremia especially.

Pharmacology

Antimicrobial class: Tetracycline derivative

Pregnancy category: D

Average serum half life: 42.0

Biliary penetration: Therapeutic

Lung penetration: Therapeutic