Vancomycin PO

C. diff Risk


Oral Bioavailability


Approximate Cost




125mg po/ng/og q6h for 10-14 days.

Intra-colonic dose
250mg in 100mL of NS by rectal enema q6h

General Information

Common Usage

Only indication is in the therapy of C. difficile infection, particularly recurrent or severe disease

Drug Monitoring

Possibility of accumulation in severe renal dysfunction.

Consider checking a vancomycin level in dialysis patients.

Additional Information

No oral absorption. May increase vancomycin resistant enterococci colonization in the gut.

Cost listed above reflects oral liquid. Capsules are almost 10X more costly


Antimicrobial class: glycopeptide

Pregnancy category: B

Average serum half life: 0.0

Urine penetration: None

CSF penetration: None

Biliary penetration: None

Lung penetration: None