C. diff Risk


Oral Bioavailability


Approximate Cost



1-2g IV q4-6h

2g IV q4h for meningitis or endocarditis

0 - 10 eGFR10 - 50 eGFR50+ eGFR1-2g IV q12-24h1-2g IV q6-12h1-2g IV q4-6h

1-2g IV q12-24h, dose after HD on dialysis days

Load 2g then 1-2g IV q6-12h

1-2g IV q12h

General Information

Common Usage

Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections especially enterococcus and listeria

Adverse Effects

Allergy and rash as for all beta-lactams.

Note: EBV-related rash - not an allergy (morbilliform rash occurring 48 hours to weeks after initial amoxicillin exposure in patients with Epstein Barr Virus does not appear to be a true drug allergy).

Rare: cytopenias, +ve Coombs

Major Interactions

Allopurinol, methotrexate, mycophenolate, warfarin, some vaccines


Antimicrobial class: aminopenicillin

Pregnancy category: B

Average serum half life: 1.0

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic