Ampicillin

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

$35/day

Dosing

Adult

1-2g IV q4-6h

2g IV q4h for meningitis or endocarditis

General Information

Common Usage

Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections especially enterococcus and listeria

Adverse Effects

Allergy and rash as for all beta-lactams.

Note: EBV-related rash - not an allergy (morbilliform rash occurring 48 hours to weeks after initial amoxicillin exposure in patients with Epstein Barr Virus does not appear to be a true drug allergy).

Rare: cytopenias, +ve Coombs

Major Interactions

Allopurinol, methotrexate, mycophenolate, warfarin, some vaccines

Pharmacology

Antimicrobial class: aminopenicillin

Pregnancy category: B

Average serum half life: 1.0

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic