Antimicrobials

Ampicillin

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

$35/day

Dosing

1-2g IV q4-6h

2g IV q4h for meningitis or endocarditis

General information

Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections especially enterococcus and listeria

Allergy and rash as for all beta-lactams.

Note: EBV-related rash - not an allergy (morbilliform rash occurring 48 hours to weeks after initial amoxicillin exposure in patients with Epstein Barr Virus does not appear to be a true drug allergy).

Rare: cytopenias, +ve Coombs

Allopurinol, methotrexate, mycophenolate, warfarin, some vaccines

Antimicrobial class: aminopenicillin

Pregnancy category: B

Average serum half life: 1.0

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic