Antimicrobials

Meropenem

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

$40/day

Dosing

500mg IV q6h or 1g IV q8h

Meningitis
2g IV q8h

General information

Therapy of serious, often nosocomial infections involving resistant gram negative organisms.

  •  Immediate and delayed-type allergy

  •  GI disturbance

  •  Cytopenias, positive Coombs

  •  Liver enzyme abnormalities

Valproic acid - Carbapenems decrease valproate levels and may decrease seizure threshold

Antimicrobial class: Carbapenem

Pregnancy category: B

Average serum half life: 1.0

Biliary penetration: Therapeutic

CSF penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic