Cefepime

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

$60/day

Dosing

Adult

2g IV q8-12h

General Information

Common Usage

Broad spectrum antimicrobial with gram positive and gram negative coverage including Pseudomonas.

Nosocomial infections involving resistant organisms.

Adverse Effects

  • Allergy (immediate & delayed)

  •  Positive Coombs

  •  Cytopenias

  •  Non-convulsive status epilepticus

Pharmacology

Antimicrobial class: 4th generation Cephalosporin

Pregnancy category: B

Average serum half life: 2.0

Biliary penetration: Moderate

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic