Ceftazidime

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

$18/day

Dosing

Adult

1-2g IV q8h

General Information

Common Usage

Broad gram negative coverage including Pseudomonas, generally used for nosocomial infections including post-neurosurgical meningitis, or other infections based on susceptibilities.

Notable lack of gram positive activity versus other cephalosporins.

Adverse Effects

  • Allergy (immediate or delayed)

  • Diarrhea

  • Cytopenias

  • Positive Coombs

  • Eosinophilia

  • Hepatic and renal laboratory abnormalities

Pharmacology

Antimicrobial class: 3rd generation Cephalosporin

Pregnancy category: B

Average serum half life: 2.0

Biliary penetration: Moderate

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic