C. diff Risk


Oral Bioavailability


Approximate Cost

IV-$15/d PO-$3/d

Spectrum Of Activity


Loading dose for Candidemia
800mg IV

Serious Infections
(e.g. Candidemia, CNS/Endophthalmitis)
400-800mg IV daily

Other indications
100-400mg IV/PO daily

0 - 50 eGFR50+ eGFR100-200mg IV/PO q24h (400 mg q24h for more aggressive therapy)400mg IV/PO q24h

Give full dose by indication after each HD session

400mg IV/PO q24h (800 mg IV q24h for more aggressive therapy)

General Information

Common Usage

Candida infections both mucocutaneous and invasive - i.e. Candidemia.

Cryptococcus and Coccidioides infections.

Antifungal prophylaxis in immunocompromised.

Drug Monitoring

Consider QTc monitoring if concomitant drugs affecting the interval or elevated baseline measurement.

Adverse Effects

  • Drug interactions

  • QTc prolongation

  • Hepatic enzyme abnormalities

  • Rash

  • Alopecia

  • GI upset

Major Interactions

Many via CYP450 - suggest review specific patient medications.

Fluconazole increases levels of phenytoin, cyclosporine, tacrolimus, warfarin, oral hypoglycemics.

Risk when combining with other QTc prolonging medications.


Antimicrobial class: Triazole antifungal, decreases ergosterol synthesis

Pregnancy category: C

Average serum half life: 20.0

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Therapeutic