600mg PO/IV q12h
Targeted or empiric therapy for gram positive infections including skin and soft tissue, and pneumonia.
Covers MRSA and VRE.
CBC at least once/week.
Visual testing for therapy >3mo or if symptoms develop on therapy.
Myelosuppression (usually with >2weeks therapy)- reversible
Peripheral/optic neuropathy with prolonged courses
Elevated liver enzymes
SSRI and other serotonergics/MAOIs- increased risk of serotonin syndrome.
Rifampin decreases linezolid levels.
Antimicrobial class: Oxazolidinone
Pregnancy category: C
Average serum half life: 5.0
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Therapeutic