500mg IV/PO q12h
Intra-abdominal, central nervous system and Clostridium difficile infections
500mg PO/IV q8h
Consider dose reduction with severe hepatic impairment (Child-Pugh C)
Suspected or confirmed anaerobic infections including:
Central nervous system
Also used in:
With prolonged therapy (>6wks) or if symptoms develop assess for peripheral/optic neuropathy
GI symptoms common- especially nausea/vomiting and metallic taste.
Peripheral/optic neuropathy with extended therapy.
Disulfiram-like reaction (severe vomiting).
Rare neurotoxicity including aseptic meningitis and encephalopathy.
Ethanol - Disulfiram-like reaction
Increases levels of:
Bacterial, protozoal and ameobic DNA is fragmented by reactive nitroso-imidazole radicals
Antimicrobial class: Nitroimidazole
Pregnancy category: B
Average serum half life: 10.0
Urine penetration: Poor
Biliary penetration: Therapeutic
Lung penetration: Therapeutic
CSF penetration: Therapeutic