Hospital Formulary Status Yes (PO solid, parenteral inj)
In-Hospital Cost will be updated
PharmaCare Formulary Status Yes (PO solid, parenteral inj, cream, gel, powder)
Special Authority None
PharmaCare Coverage
250mg PO - $0.0710/tab
500mg PO - $0.5917/cap
Pfizer 500mg/0.1L liquid for inj - $0.187812/ml
Baxter 500mg/0.1L liquid for inj - $0.0296/ml
Powder (topical use) - $0.7500/g
1% cream - $0.7223/g
1% gel - $0.7291/g
0.75% vaginal gel - $0.3356/g
10% vaginal cream - $0.2763/g
Outpatient Cost 250mg PO - $0.07-0.23/tab 500mg PO - $0.59-0.69/cap Pfizer 500mg/0.1L liquid for inj - $0.19-0.21/ml Baxter 500mg/0.1L liquid for inj - $0.03-0.04/ml Powder (topical use) - $0.43-0.47/g 1% cream - $0.72-0.79/g 1% gel - $0.73-0.80/g 0.75% vaginal gel - $0.34-0.37/g 10% vaginal cream - $0.28-0.30/g
Suspected or confirmed anaerobic infections including:
Also used in:
With prolonged therapy (>6wks) or if symptoms develop assess for peripheral/optic neuropathy
Gastrointestinal (PO and IV)
Neurotoxicity (mainly with IV)
Allergic reactions (PO and IV)
Genitourinary (PO, IV and PV)
Disulfiram-like reactions (PO, IV and PV)
Other
Ethanol - Disulfiram-like reaction
Increases levels of:
Antimicrobial class: Nitroimidazole
Pregnancy category: B
Bacterial, protozoal and ameobic DNA is fragmented by reactive nitroso-imidazole radicals
Average serum half life: 10.0 hr
Biliary penetration: Therapeutic
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Poor