400mg IV/PO daily
Pneumonia including CAP, HAP, aspiration
Some intra-abdominal infections
Monitor QTc in patients with increased risk
CNS toxicity including confusion, psychosis
Tendinopathy and rupture
Weakness exacerbation in myasthenia gravis
QTc prolongation - Increased risk with other agents that prolong QTc.
Divalent cations including Ca, Mg - Decreased absorption.
Warfarin - Increased INR.
Rifampin - Decrease moxifloxacin levels.
Antimicrobial class: Fluoroquinolone
Pregnancy category: C
Average serum half life: 12.0
Biliary penetration: Therapeutic
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Poor