Penicillin G

C. diff Risk


Oral Bioavailability


Approximate Cost



12-24 million units/day IV in 6 divided doses

0 - 10 eGFR10 - 50 eGFR50+ eGFR0.5-4MU IV q12h0.5-4MU IV q8h0.5-4MU IV q4h

Up to 2 million units IV q4h.

Administer after dialysis on HD days.

Pharmacist review recommended.

2 million units IV q4h

General Information

Therapy of Streptococcal and other documented susceptible infections, syphilis

  • Allergy/rash (immediate or delayed)

  • Seizures

  • Cytopenias

  • Eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes

  • Serum sickness

Antimicrobial class: penicillin

Pregnancy category: B

Average serum half life: 1.0

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Moderate

Biliary penetration: Therapeutic