Penicillin G

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

IV-$20/d

Dosing

Adult

12-24 million units/day IV in 6 divided doses

General Information

Common Usage

Therapy of Streptococcal and other documented susceptible infections, syphilis

Adverse Effects

  • Allergy/rash (immediate or delayed)

  • Seizures

  • Cytopenias

  • Eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes

  • Serum sickness

Pharmacology

Antimicrobial class: penicillin

Pregnancy category: B

Average serum half life: 1.0

Biliary penetration: Therapeutic

CSF penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic