Amoxicillin

C. diff Risk

Low

Oral Bioavailability

Excellent

Approximate Cost

$0.50/day

Dosing

500-1000mg po TID

0 - 10 eGFR10 - 50 eGFR50+ eGFR500mg PO q24h500mg PO q8-12h500-1000mg PO q8h

500-1000mg po q24h - take after dialysis on HD days

General Information

Therapy of Streptococcal, Enterococcal infections as well as susceptible gram negative infections.

Commonly used for upper respiratory infections, urinary tract infection, dental infections.

  • Allergy/rash (immediate or delayed)

  • ¬†Cytopenias

Note: EBV-related rash - not an allergy (morbilliform rash occurring 48 hours to weeks after initial amoxicillin exposure in patients with Epstein Barr Virus does not appear to be a true drug allergy).

Allopurinol, methotrexate, mycophenolate, warfarin, some vaccines

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1.0

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Moderate

Biliary penetration: Therapeutic