C. diff Risk


Oral Bioavailability


Approximate Cost



500-1000mg po TID

General Information

Common Usage

Therapy of Streptococcal, Enterococcal infections as well as susceptible gram negative infections.

Commonly used for upper respiratory infections, urinary tract infection, dental infections

Adverse Effects

  • Allergy/rash (immediate or delayed)

  • ¬†Cytopenias

Note: EBV-related rash - not an allergy (morbilliform rash occurring 48 hours to weeks after initial amoxicillin exposure in patients with Epstein Barr Virus does not appear to be a true drug allergy)

Major Interactions

Allopurinol, methotrexate, mycophenolate, warfarin, some vaccines


Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1.0

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Moderate

Biliary penetration: Therapeutic