Antimicrobials

Amoxicillin

C. diff Risk

Low

Oral Bioavailability

Excellent

Approximate Cost

$0.50/day

Dosing

500-1000mg po TID

General information

Therapy of Streptococcal, Enterococcal infections as well as susceptible gram negative infections.

Commonly used for upper respiratory infections, urinary tract infection, dental infections

  • Allergy/rash (immediate or delayed)

  • ¬†Cytopenias

Note: EBV-related rash - not an allergy (morbilliform rash occurring 48 hours to weeks after initial amoxicillin exposure in patients with Epstein Barr Virus does not appear to be a true drug allergy)

Allopurinol, methotrexate, mycophenolate, warfarin, some vaccines

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1.0

Biliary penetration: Therapeutic

CSF penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic