Amoxicillin

C. diff Risk

Low

Oral Bioavailability

Excellent

Approximate Cost

$0.50/day

Dosing

Adult

500-1000mg po TID

General Information

Common Usage

Therapy of Streptococcal, Enterococcal infections as well as susceptible gram negative infections.

Commonly used for upper respiratory infections, urinary tract infection, dental infections

Adverse Effects

  • Allergy/rash (immediate or delayed)

  • ¬†Cytopenias

Note: EBV-related rash - not an allergy (morbilliform rash occurring 48 hours to weeks after initial amoxicillin exposure in patients with Epstein Barr Virus does not appear to be a true drug allergy)

Major Interactions

Allopurinol, methotrexate, mycophenolate, warfarin, some vaccines

Pharmacology

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1.0

Biliary penetration: Therapeutic

CSF penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic