Antimicrobials

Trimethoprim-Sulfamethoxazole

C. diff Risk

Low

Oral Bioavailability

Excellent

Approximate Cost

IV$100/d PO$1/d

Dosing

PO: 1-2 DS tabs PO BID
IV: 15-20mg/kg/day of TMP IV in 4 divided doses

General information

  •  Urinary tract infections

  •  Susceptible MRSA infections

  •  Stenotrophomonas infections

  •  Pneumocystis jirovecii pneumonia (Treatment or prophylaxis)

Follow creatinine and electrolytes in patients at increased risk renal failure, hyperkalemia.

  •  Gastrointestinal upset common

  •  Bone marrow suppression

  •  Hyperkalemia

  •  Renal failure

  •  Hepatitis

  •  Aseptic meningitis

  •  Stevens Johnson syndrome/toxic epidermal necrolysis

  •  Other rashes

ACEi - Increased serum potassium level.

Increases amantadine levels.

Decreases cyclosporine.

Methotrexate- marrow suppression.

Increases phenytoin.

Increases rifampin.

Increases INR with warfarin.

Antimicrobial class: Sulfonamide - Antifolate

Pregnancy category: C

Average serum half life: 10.0

Biliary penetration: Moderate

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic