Antimicrobials

Levofloxacin

C. diff Risk

High

Oral Bioavailability

Excellent

Approximate Cost

Dosing

500-750mg PO/IV daily

General information

  • Lower respiratory infection (CAP, HAP)

  • Intraabdominal infection

Monitor QTc in patients with increased risk

  • QTc prolongation

  • Dysglycemia

  • CNS toxicity including confusion, psychosis

  • Tendinopathy and rupture

  • GI upset

  • Weakness exacerbation in myasthenia gravis

  • Rash

  • Other QTc prolonging agents

  • Divalent cations - decreased absorption

  • NSAIDs - increase seizure risk

  • Warfarin - increased INR

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 7.0

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic