Norfloxacin

C. diff Risk

High

Oral Bioavailability

Moderate

Approximate Cost

$2/day

Dosing

Adult

400mg PO BID

General Information

Common Usage

Prophylaxis of spontaneous bacterial peritonitis

Uncomplicated UTI

Drug Monitoring

Monitor QTc in patients with increased risk

Adverse Effects

  • QTc prolongation

  • Dysglycemia

  • CNS toxicity including confusion, psychosis

  • Tendinopathy and rupture

  • GI upset

  • Weakness exacerbation in myasthenia gravis

  • Rash

Major Interactions

Other QTc prolonging agents.

Divalent cations - Decreased absoprtion.

Methadone - Increased seizures.

Thyroid replacement - Decreases T.

Warfarin - Increased INR.

Pharmacology

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 4.0

Biliary penetration: Therapeutic

CSF penetration: Poor

Urine penetration: Therapeutic