C. diff Risk


Oral Bioavailability


Approximate Cost


Spectrum Of Activity


400mg PO BID

0 - 30.0 30.0+ 400mg PO q24h400mg PO q12h

400mg PO daily

General Information

Common Usage

Prophylaxis of spontaneous bacterial peritonitis

Uncomplicated UTI

Drug Monitoring

Monitor QTc in patients with increased risk

Adverse Effects

  • QTc prolongation

  • Dysglycemia

  • CNS toxicity including confusion, psychosis

  • Tendinopathy and rupture

  • GI upset

  • Weakness exacerbation in myasthenia gravis

  • Rash

Major Interactions

Other QTc prolonging agents.

Divalent cations - Decreased absoprtion.

Methadone - Increased seizures.

Thyroid replacement - Decreases T.

Warfarin - Increased INR.


Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 4.0

Biliary penetration: Therapeutic

CSF penetration: Poor

Urine penetration: Therapeutic