Antimicrobials

Nitrofurantoin

C. diff Risk

Low

Oral Bioavailability

Excellent

Approximate Cost

$1/day

Dosing

Cystitis
Macrobid 100mg PO BID

General information

Uncomplicated cystitis in females with normal renal function.

Interstitial pneumonitis and fibrosis esp. with prolonged use.

Peripheral neuropathy.

Antacids decrease absorption.

Think of this drug as a urinary antiseptic.

Not recommended in males due to inadequate tissue penetration, esp. with possible occult prostatitis.

Antimicrobial class: Nitrofuran

Pregnancy category: B

Average serum half life: 1.0

Biliary penetration: None

CSF penetration: None

Lung penetration: None

Urine penetration: Therapeutic