Spectrum: Local Antimicrobial Stewardship Spectrum: Local Antimicrobial Stewardship, for Island Health
Antimicrobials
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Nitrofurantoin

C. diff Risk

Low

Oral Bioavailability

Excellent

Approximate Cost

$1/day

Antibiogram Data

General Spectrum of Activity
Spectrum of activity

Dosing

Adult
Adult

Cystitis
Macrobid 100mg PO BID

Renal
Renal

General information

Common Usage
Common Usage

Uncomplicated cystitis in females with normal renal function.

Adverse Effects
Adverse Effects

Interstitial pneumonitis and fibrosis esp. with prolonged use.

Peripheral neuropathy.

Major Interactions
Major Interactions

Antacids decrease absorption.

Additional Information
Additional Information

Think of this drug as a urinary antiseptic.

Not recommended in males due to inadequate tissue penetration, esp. with possible occult prostatitis.

Pharmacology
Pharmacology

Antimicrobial class: Nitrofuran

Pregnancy category: B

Average serum half life: 1.0

Biliary penetration: None

CSF penetration: None

Lung penetration: None

Urine penetration: Therapeutic