Nitrofurantoin

C. diff Risk

Low

Oral Bioavailability

Excellent

Approximate Cost

$1/day

Dosing

Adult

Cystitis
Macrobid 100mg PO BID

General Information

Common Usage

Uncomplicated cystitis in females with normal renal function. Not recommended for pyelonephritis. Not recommended in males due to inadequate tissue penetration, esp. with possible occult prostatitis.

Adverse Effects

Interstitial pneumonitis and fibrosis esp. with prolonged use.

Peripheral neuropathy.

Major Interactions

Antacids decrease absorption.

Additional Information

Not recommended in males due to inadequate tissue penetration, esp. with possible occult prostatitis.

Pharmacology

Antimicrobial class: Nitrofuran

Pregnancy category: B

Average serum half life: 1.0

Biliary penetration: None

CSF penetration: None

Lung penetration: None

Urine penetration: Therapeutic