Spectrum: Local Antimicrobial Stewardship, for Island Health

Cefuroxime

C. diff Risk

Medium

Oral Bioavailability

Moderate

Approximate Cost

IV-15$/d PO-4$/d

Spectrum Of Activity

Spectrum Of Activity

Antibiogram Data

Dosing

Adult

750-1500mg IV q8h

500mg PO q12h

Renal

0 - 29 eGFR30+ eGFR250-500mg PO BID500mg PO BID

0 - 29 eGFR30 - 50 eGFR50+ eGFR750 - 1500 mg IV q12-24h750 - 1500 mg IV q8-12h750 - 1500 mg IV q8h

750-1500mg IV q24h, give dose after HD on dialysis days

500-750mg PO BID after HD, give dose after HD on dialysis days

750-1500mg IV q8h

750-1500 mg IV q24h
250-500 mg PO BID

General Information

Common Usage

  •  Community acquired pneumonia with a macrolide

  •  Intraabdominal infection

  •  Epiglottitis

Adverse Effects

  •  Allergy (immediate & delayed)

  •  Positive Coombs

  •  Cytopenias

  •  GI upset

  •  Diarrhea

  •  Abnormal liver enzymes

Major Interactions

None significant; potential increase in INR with warfarin

Pharmacology

Antimicrobial class: 2nd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2.0

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic