Spectrum: Local Antimicrobial Stewardship Spectrum: Local Antimicrobial Stewardship, for Island Health
Antimicrobials
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Cefuroxime

C. diff Risk

Medium

Oral Bioavailability

Moderate

Approximate Cost

IV-15$/d PO-4$/d

Antibiogram Data

General Spectrum of Activity
Spectrum of activity

Dosing

Adult
Adult

750-1500mg IV q8h

500mg PO q12h

Renal
Renal

General information

Common Usage
Common Usage

  •  Community acquired pneumonia with a macrolide

  •  Intraabdominal infection

  •  Epiglottitis

Adverse Effects
Adverse Effects

  •  Allergy (immediate & delayed)

  •  Positive Coombs

  •  Cytopenias

  •  GI upset

  •  Diarrhea

  •  Abnormal liver enzymes

Major Interactions
Major Interactions

None significant; potential increase in INR with warfarin

Pharmacology
Pharmacology

Antimicrobial class: 2nd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2.0

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic