Cefuroxime - Renal Dosing

In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.

If worsening renal function, actual GFR is likely lower than calculated.

If improving renal function, actual GFR is likely higher than calculated eGFR.

0 - 29 eGFR

250-500mg PO BID

30+ eGFR

500mg PO BID

0 - 29 eGFR

750 - 1500 mg IV q12-24h

30 - 50 eGFR

750 - 1500 mg IV q8-12h

50+ eGFR

750 - 1500 mg IV q8h

750-1500mg IV q24h, give dose after HD on dialysis days

500-750mg PO BID after HD, give dose after HD on dialysis days

750-1500mg IV q8h

750-1500 mg IV q24h
250-500 mg PO BID