Oseltamivir

C. diff Risk

None

Oral Bioavailability

Excellent

Approximate Cost

$8/day

Spectrum Of Activity

Dosing

Standard Dosing
75mg PO BID x 5 days

Critically Ill, Severely Immunocompromised or in Intensive Care Unit
75-150mg PO BID x 5 days or longer (double dosing or prolonged duration of therapy is based on expert opinion only)

Prophylaxis
75mg PO daily x 10 days for those exposed, or for duration of outbreak

eGFR = 30 to 59 ml/mineGFR = 10 to 29 ml/minTreatment: 30mg PO BID x 5 days; certain resources also support 75mg PO daily x 5 days

Prophylaxis: 30mg PO daily x 10 days for exposures or for duration of outbreak Treatment: 30mg PO daily x 5 days

Prophylaxis: 30mg PO every OTHER day x 10 days for exposures or for duration of outbreak

Treatment: 75mg PO load then 75mg PO after each HD session for 5 day period

Prophylaxis: 30mg PO load then 30mg PO after each HD session x 10 days for exposures or for duration of outbreak

Treatment: 30mg PO daily x 5 days

Prophylaxis: 30mg PO daily x 10 days for exposures or for duration of outbreak

General Information

Common Usage

Treatment and prophylaxis of influenza

Adverse Effects

  • GI upset common

  • Rare - Stevens Johnson

  • Neuropsychiatric side effects reported

Major Interactions

No significant

Additional Information

Higher doses have not been shown to be superior but may be considered in critically ill or obese patients i.e. 150mg PO BID

Pharmacology

Antimicrobial class: Antiviral - neuraminidase inhibitor

Pregnancy category: C

Average serum half life: 2.0

Lung penetration: Therapeutic