Antimicrobials

Oseltamivir

C. diff Risk

None

Oral Bioavailability

Excellent

Approximate Cost

$8/day

Dosing

Immunocompromised or critically ill
75mg PO BID x 5 days or longer

Prophylaxis
75mg PO daily

General information

Treatment and prophylaxis of influenza

  • GI upset common

  • Rare - Stevens Johnson

  • Neuropsychiatric side effects reported

Higher doses have not been shown to be superior but may be considered in critically ill or obese patients i.e. 150mg PO BID

Antimicrobial class: Antiviral - neuraminidase inhibitor

Pregnancy category: C

Average serum half life: 2.0

Lung penetration: Therapeutic