Antimicrobials

Fosfomycin

C. diff Risk

Low

Oral Bioavailability

Moderate

Approximate Cost

$25/3g

Dosing

Female, Uncomplicated UTI
3g PO once in 90-120 mL of water

Complicated UTI
3g PO q2-3days x 3 doses

Intermittent Dialysis
Dose post-hemodialysis

General information

Urinary Tract Infection, especially involving ESBL-producing organisms

  •  GI upset, especially diarrhea

  •  Headache

  •  Eosinophilia, neutropenia

  •  Hypokalemia

IV formulation not available.

Pharmacology: Inhibits bacterial cell wall synthesis by inactivating important enzyme (pyruvyl transferase)

Antimicrobial class: Phosphonic acid derivative

Pregnancy category: B

Average serum half life: 6.0

Urine penetration: Therapeutic