Hospital Formulary Status Yes (PO solid, PO soln, parenteral inj)
In-Hospital Cost will be updated
PharmaCare Formulary Status Yes (PO solid, PO susp, topical)
Special Authority None
PharmaCare Coverage 200mg PO - $0.6909/tab 400mg PO - $1.3716/tab 800mg PO - $1.3687/tab 200mg/5ml PO susp - $0.2801/ml 5% ointment - $13.2963/g
Outpatient Cost 200mg PO - $0.69-0.94/tab 400mg PO - $1.37-1.60/tab 800mg PO - $1.39-1.60/tab 200mg/5ml PO susp - $0.28-0.31/ml 50mg/ml inj - $135.91-149.50/vial (10ml) 50mg/ml inj - $271.79-298.97/vial (20ml) 5% ointment - $13.30-14.63/g 5% cream - $16.59-18.25/g
Therapy for herpesviral infections (HSV and VZV) including encephalitis
Prophylaxis of herpesviral infections if recurrent disease or immunocompromised
If IV acyclovir, follow SCr daily; pre-hydration helpful
Check urine for crystals if suspect AKI
Malaise (PO)
Acute renal failure (IV)
Decrease in absolute neutrophil count (IV)
Decrease in hemoglobin (IV)
Neurotoxicity (PO and IV)
Concomitant nephrotoxins
Acyclovir may increase serum concentration of clozapine, mycophenolate, zidovudine, tenofovir
May diminish efficacy of zoster or varicella vaccine
Antimicrobial class: Antiviral, Nucleoside Analogue
Pregnancy category: B
For oral indications, Valacyclovir is the pro-drug and is more bioavailable with more convenient dosing
Average serum half life: 3.0 hr
CSF penetration: Therapeutic
Urine penetration: Therapeutic