Colistin

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

Dosing

Adult

Dosed in colistin base:

Critically Ill
300 mg IV load, then 150 mg IV q12h or 2.5-5 mg IV daily (divided q12h)

Cystic Fibrosis
3 mg/kg/day in 3 divided doses

General Information

Common Usage

Infections caused by Carbapenemase-producing organisms.

Drug Monitoring

Renal function

Adverse Effects

  • Acute renal failure

  • Muscle weakness

  • Paresthesias

  • Slurred speech

  • Vertigo

Major Interactions

Nephrotoxins.

Concurrent use or pre-administration of other neuromuscular blocking agents, which can interfere with neuromuscular function.

Additional Information

Avoid in myasthenia gravis.

Pharmacology

Antimicrobial class: cationic detergent

Average serum half life: 2.5 hours

CSF penetration: No