Coronavirus Disease (COVID-19)

Refers to a viral syndrome caused by the novel Coronavirus SARS-CoV-2

Microbiology

SARS-CoV-19 is an RNA Coronavirus that causes the disease COVID-19

It is related to the coronaviruses that cause SARS and MERS

Concomitant viral or bacterial pathogens at presentation have not been widely described with COVID-19

Secondary bacterial infection can occur in ~15% of patients particularly in those receiving mechanical ventilation

More Information

  1. Centers for Disease Control and Prevention. Interim clinical guidance for management of patients with confirmed Coronavirus Disease (COVID-19). Updated March 7, 2020. [https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-guidance-management-patients.html]
  2. World Health Organization. Clinical management of severe acute respiratory infection when COVID-19 disease is suspected. Interim guidance, March 21, 2020. [https://www.who.int/publications-detail/clinical-management-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)-infection-is-suspected]
  3. Metlay JP et al. Diagnosis and treatment of adults with community-acquired pneumonia. An official clinical practice guideline of the American Thoracic Society and Infectious Diseases Society of America. Am J Respir Crit Care Med. 2019;200:e45. [https://doi.org/10.1164/rccm.201908-1581ST]
  4. World Health Organization. Report of the WHO-China joint mission on Coronavirus Disease 2019 (COVID-19). February 24, 2020. [https://www.who.int/docs/default-source/coronaviruse/who-china-joint-mission-on-covid-19-final-report.pdf]
  5. Novel coronavirus pneumonia emergency response epidemiology team. The epidemiological characteristics of an outbreak of 2019 novel Coronavirus Disease (COVID-19) – China, 2020. China CDC Weekly. 2020;2:113. [http://weekly.chinacdc.cn/en/article/id/e53946e2-c6c4-41e9-9a9b-fea8db1a8f51]
  6. Huang C et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020; 395:497. [https://doi.org/10.1016/S0140-6736(20)30183-5]
  7. Chen N et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395:507. [https://doi.org/10.1016/S0140-6736(20)30211-7]
  8. Wang D et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020. [https://doi.org/10.1001/jama.2020.1585]
  9. Zhou F et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020. [https://doi.org/10.1016/S0140-6736(20)30566-3]
  10. Young BE et al. Epidemiological features and clinical course of patients infected with SARS-CoV-2 in Singapore. JAMA. 2020. [https://doi.org/10.1001/jama.2020.3204]
  11. BC Centre for Disease Control. COVID-19 Care – Lab Testing. March 15, 2020. http://www.bccdc.ca/health-professionals/clinical-resources/covid-19-care/lab-testing
  12. Alhazzani W et al. Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19). [ccmjournal.org; currently in press]

Thank you to Fraser Health for providing the pathway template. Many sections are adapted from FH.