Ceftaroline - Renal Dosing

In the setting of rapidly improving or worsening renal function, calculations of CrCl are inaccurate. Dosing should be based on estimated renal function instead.

If improving renal function, actual CrCl is likely higher than calculated CrCl.

If worsening renal function, actual CrCl is likely lower than calculated CrCl.

CrCl >50 mL/min

600mg IV Q12h

CrCl 30-50 mL/min

400mg IV Q12h

CrCl 16-30 mL/min

300mg IV Q12h

CrCl ≤15 mL/min

200mg IV Q12h

200mg IV Q12h (doses given on HD days should be given after HD)

400mg IV Q12h