Ceftazidime/Avibactam

Restricted
C difficile risk
High
Oral Bioavailability
N/A

Dosing

NO NEW STARTS. ID Consult or Antimicrobial Stewardship Review Consult is required for alternative therapies.

CrCl >50 mL/minCrCl 30-50 mL/minCrCl 16-30 mL/minCrCl 6-15 mL/min2.5g IV Q8h1.25g IV Q8h0.94g IV Q12h0.94g IV Q24h

CrCl 6-15 mL/minCrCl ≤5 mL/min0.94g IV Q24h0.94g IV Q48h

CRRT rate 3-4 L/hrCRRT rate 1-2 L/hr1.25g IV Q8h0.94g IV Q12h

General Information

Antimicrobial Stewardship approved criteria must be indicated at ORDER ENTRY.

Approved Indications:

  1. Documented, non-urine CRE (e.g. KPC)