Ceftazidime/Avibactam - Renal Dosing

In the setting of rapidly improving or worsening renal function, calculations of CrCl are inaccurate. Dosing should be based on estimated renal function instead.

If improving renal function, actual CrCl is likely higher than calculated CrCl.

If worsening renal function, actual CrCl is likely lower than calculated CrCl.

CrCl >50 mL/min

2.5g IV Q8h

CrCl 30-50 mL/min

1.25g IV Q8h

CrCl 16-30 mL/min

0.94g IV Q12h

CrCl 6-15 mL/min

0.94g IV Q24h

CrCl 6-15 mL/min

0.94g IV Q24h

CrCl ≤5 mL/min

0.94g IV Q48h

CRRT rate 3-4 L/hr

1.25g IV Q8h

CRRT rate 1-2 L/hr

0.94g IV Q12h