Ceftolozane/Tazobactam - Renal Dosing

In the setting of rapidly improving or worsening renal function, calculations of CrCl are inaccurate. Dosing should be based on estimated renal function instead.

If improving renal function, actual CrCl is likely higher than calculated CrCl.

If worsening renal function, actual CrCl is likely lower than calculated CrCl.

CrCl >50 mL/min

1.5g IV Q8h

CrCl 30-50 mL/min

750mg IV Q8h

CrCl 16-30 mL/min

375mg IV Q12h

CrCl ≤15 mL/min

No recommendations

Load 750mg IV, then 150mg IV Q8h

1.5g IV Q8h