Imipenem/Cilastatin

Restricted
C difficile risk
High
Oral Bioavailability
N/A
Cost
$$$

Dosing

CrCl ≥30 mL/minCrCl 10-29 mL/minCrCl <10 mL/min500mg IV Q6h or 1000mg IV Q8h500mg IV Q12hShould not receive unless HD to be initiated

500-1000mg IV Q24h (doses given on HD days should be given after HD)

500mg IV Q24h

General Information

Antimicrobial Stewardship approved criteria must be indicated at ORDER ENTRY.

Approved Indications:

  1. Documented infection with P.aeruginosa
  2. Penicillin AND cephalosporin allergies
  3. High suspicion for ESBLs or P.aeruginosa