Ganciclovir - Renal Dosing

In the setting of rapidly improving or worsening renal function, calculations of CrCl are inaccurate. Dosing should be based on estimated renal function instead.

If improving renal function, actual CrCl is likely higher than calculated CrCl.

If worsening renal function, actual CrCl is likely lower than calculated CrCl.

CrCl >50 mL/min

5 mg/kg IV Q12h

CrCl 30-50 mL/min

2.5 mg/kg IV Q12h

CrCl 10-29 mL/min

2.5 mg/kg IV Q24h

CrCl <10 mL/min

1.25 mg/kg IV Q24h

1.25 mg/kg/dose IV TIW after HD

2.5 mg/kg IV Q24h