Valganciclovir - Renal Dosing

In the setting of rapidly improving or worsening renal function, calculations of CrCl are inaccurate. Dosing should be based on estimated renal function instead.

If improving renal function, actual CrCl is likely higher than calculated CrCl.

If worsening renal function, actual CrCl is likely lower than calculated CrCl.

CrCl ≥80 mL/min

900mg PO Q12h

CrCl 50-80 mL/min

450mg PO Q12h

CrCl 30-50 mL/min

450mg PO Q24h

CrCl 10-29 mL/min

450mg PO Q48h

CrCl <10 mL/min

Not recommended