C difficile risk
Oral Bioavailability

Spectrum Of Activity


CrCl ≥30 mL/minCrCl 10-29 mL/minCrCl <10 mL/min500mg PO Q8h or 875mg PO Q12h250-500mg PO Q12h250-500mg PO Q24h

250-500mg PO Q24h (doses given on HD days should be given after HD)

500-1000mg po TID

General Information

Therapy of Streptococcal and Enterococcal infections as well as susceptible gram negative infections.

Commonly used for upper respiratory infections and urinary tract infections.

  • Allergy/rash (immediate or delayed)

  • Note EBV related rash

  • Cytopenias

Allopurinol - increased rash

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic