Amoxicillin
Renal

Renal

In the setting of rapidly improving or worsening renal function, calculations of CrCl are inaccurate. Dosing should be based on estimated renal function instead.

If improving renal function, actual CrCl is likely higher than calculated CrCl.

If worsening renal function, actual CrCl is likely lower than calculated CrCl.

Not On Dialysis

CrCl ≥30 mL/min

500-1000mg PO Q8h or 875mg PO Q12h

CrCl 10-30mL/min

500-1000mg PO Q12h

CrCl <10 mL/min

250-500mg PO Q24h

Intermittent Dialysis (IHD)

250-500mg PO Q24h (doses given on HD days should be given after HD)