Amoxicillin/Clavulanate

C difficile risk
Medium
Oral Bioavailability
Excellent
Cost
$

Dosing

CrCl ≥30 mL/minCrCl 10-29 mL/minCrCl <10 mL/min500mg PO Q8h or 875mg PO Q12h250-500mg PO Q12h250-500mg PO Q24h

250-500mg Q24h (doses given on HD days should be given after HD), do not use 875mg or ER tablet

875mg PO BID or 500mg PO TID of the amoxicillin component

General Information

Prophylaxis/treatment of bite wounds.

Polymicrobial infections of the respiratory tract or abdomen.

Skin and soft tissue infections.

For prolonged therapy, monitor liver enzymes and function.

  • Allergy/rash (immediate or delayed)

  • Note EBV related rash

  • Cytopenias

  • Diarrhea

  • Hepatotoxicity due to clavulinate - usually mild, liver failure is rare.

Increased risk of rash with allopurinol

Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic